Dra. Libia Vega Loyo

e-mail: lvega@cinvestav.mx
Teléfono: +52 5747-3800 ext. 5427
Fax: +52 55 5747-3395

Investigador Cinvestav 3D

Laboratorio de Genética Toxicológica e Inmunotoxicología

Doctora en Ciencias en Investigación Biomédica Básica, 1998, UNAM. México.

Estancia posdoctoral 1998-1999. Laboratorio de Toxicología, Immunotoxicología. Instituto Nacional de Ciencias de Salud Ambiental/Institutos Nacionales de Salud, Research Triangle Park, NC, EUA.

Estancia sabática 2010-2011. Laboratorio de Toxicología, Reacciones Adversas a Fármacos. Universidad de Toronto, Toronto, Ontario, Canadá.

Investigador Nacional Nivel II
 

Líneas de Investigación

  • Genotoxicidad de xenobióticos, fármacos y compuestos naturales en modelos in vivo e in vitro.
  • Evaluación de compuestos antineoplásicos y estudios preclínicos.
  • Inmunotoxicidad en poblaciones humanas, en estudios in vitro y en modelos animales expuestos a xenobióticos, genotóxicos y carcinogénicos (arsénico, selenio, plaguicidas organofosforados, disolventes orgánicos, etc.) y producidos por compuestos naturales con potencial farmacológico.
  • Participación del receptor de hidrocarburos arilo (AhR) en la regulación de la respuesta inmune y en los efectos genotóxico de xenobióticos.
  • Mecanismos moleculares de alteraciones en la actividad y función de células inmunes.
ArtículosEstudiantesDonativos y Distinciones

Olivares-Bañuelos TN, Martínez-Hernández MI, Hernández-Kelly LC, Chi-Castañeda D, Vega L, Ortega A. The neurotoxin diethyl ditiophosphate impairs glutamate transport in cultured Bergmann glia cells. Neurochemistry International 123: 77-84, 2019. DOI: 10.1016/j.neuint.2018.06.004.

Domínguez-Acosta O, Vega L, Estrada-Muñiz E, Rodríguez MS, Gonzalez FJ, Elizondo G. Activation of aryl hydrocarbon receptor regulates the LPS/IFNg-induced inflammatory response by inducing ubiquitin-proteasomal and lysosomal degradation of RelA/p65. Biochemical Pharmacology, 155: 141-149, 2008. DOI: 10.1016/j.bcp.2018.06.016.

García-Niño WR, Estrada-Muñiz E, Valverde M, Reyes-Chilpa R, Vega L. Cytogenetic effects of Jacareubin from Calophyllum brasiliense on human peripheral blood mononucleated cells in vitro and on mouse polychromatic erythrocytes in vivo. Toxicology and Applied Pharmacology, 335: 6-15, 2017. DOI: 10.1016/j.taap.2017.09.018.

Climaco-Arvizu S, Domínguez-Acosta O, Cabañas-Cortés MA, Rodríguez-Sosa M, Gonzalez FJ, Vega L, Elizondo G. Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization. Life Sciences, 155: 76-84, 2016. DOI: 10.1016/j.lfs.2016.05.001.

Gnanaprakasam JNR, Estrada-Muñiz E, Vega L. The anacardic 6-pentadecyl salicylic acid induces macrophage activation via the phosphorylation of ERK1/2, JNK, p38 kinases and NF-kB. International Immunopharmacology, 29: 808-817, 2015. DOI: 10.1016/j.intimp.2015.08.038.

Metushi IG, Cai P, Vega L, Grant DM, Uetrecht J. Paradoxical Attenuation of Autoimmune Hepatitis by Oral Isoniazid in Wild-Type and N-Acetyltransferase-Deficient Mice. Drug Metabolism and Disposition, 42: 963-973, 2014. DOI: 10.1124/dmd.113.056622.

Rodríguez Sosa M, García Montalvo EA, Del Razo LM, Vega L. Effect of Selenomethionine Supplementation in Food on the Excretion and Toxicity of Arsenic Exposure in Female Mice. Biological Trace Element Research, 156: 279-287, 2013. DOI: 10.1007/s12011-013-9855-9.

Esquivel-Sentíes MS, Vega L. Organophosphorous Pesticides Metabolite Reduces Human T CD8 Homeostasis and Proliferation by Inducing Cellular Death. Journal of Environmental and Analytical Toxicology, S4: 004, 2012. DOI:10.4172/2161-0525.S4-004.

Elizondo G, Rodríguez-Sosa M, Estrada-Muñiz E, Gonzalez FJ, Vega L. Deletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response to Leishmania major Infection. International Journal of Biological Sciences, 7(9): 1220-1229, 2011. DOI: 10.7150/ijbs.7.1220.

Esquivel-Sentíes MS, Barrera I, Ortega A, Vega, L. Organophosphorous pesticide metabolite (DEDTP) induces changes in the activation status of human lymphocytes by modulating the interleukin 2 receptor signal transduction pathway. Toxicology and Applied Pharmacology, 248: 122-133, 2010. DOI: 10.1016/j.taap.2010.07.017.

Elizondo G, Medina-Díaz IM, Cruz R, Gonzalez FJ, Vega L. Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C/EBPb interaction. BIOCHEMICAL PHARMACOLOGY, 77: 248-257, 2009 (FI 5.009, 16 citas). ISSN: 0006-2952. DOI: 10.1016/j.bcp.2008.10.011.

Cruz R, Quintana-Hau JD, González JR, Tornero-Montaño R, Baiza-Durán LM, Vega L. Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation. British Journal of Ophthalmology, 92: 120-125, 2008. DOI: 10.1136/bjo.2007.125179.

Medina-Díaz IM, Arteaga-Illán G, Bermudez de León M, Cisneros B, Sierra-Santoyo A, Vega L, Gonzalez FJ, Elizondo G. Pregnane X Receptor-Dependent Induction of the CYP3A4 Gene by o,p´-1,1,1,-Trichloro-2,2-Bis (p-Chlorophenyl)ethane. Drug Metabolism and Disposition, 35: 95-102, 2007. DOI: 10.1124/dmd.106.011759.

Soto-Peña GA, Luna AL, Acosta-Saavedra LC, Conde P, López-Carrillo L, Cebrián ME, Bastida M, Calderón-Aranda ES, Vega L. Assessment of lymphocyte subpopulations and cytokine secretion in children exposed to arsenic. FASEB Journal, 20: 779-781, 2006. DOI: 10.1096/fj.05-4860fje.

Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L. Over-production of IFN-γ and IL-12 in AhR-null mice. FEBS Letters, 579: 6403-6410, 2005. DOI: 10.1016/j.febslet.2005.10.023.

Patterson R, Vega L, Trouba K, Bortner C, Germolec D. Arsenic-induced alterations in the contact hypersensitivity response in Balb/c mice. Toxicology and Applied Pharmacology, 198: 434-443, 2004. DOI: 10.1016/j.taap.2003.10.012.

Blood-Siegfried J, Nyska A, Lieder H, Joe M, Vega L, Patterson R, Germolec D. Synergisitc Effect of Influenza A virus on Endotoxin-Induced Mortality in Rat Pups: A Potential Model for Sudden Infant Death Syndrome. Pediatric Research, 54(4): 481-490, 2002. DOI: 10.1203/01.PDR.0000028250.96650.D7.

Vega L, Styblo M, Patterson R, Cullen W, Wang C, Germolec D. Differential Effects of Trivalent and Pentavalent Arsenicals on Cell Proliferation and Cytokine Secretion in Normal Human Epidermal Keratinocytes. Toxicology and Applied Pharmacology 172: 225-232, 2001. DOI: 10.1006/taap.2001.9152.

Styblo M, Del Razo LM, Vega L, Germolec DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, Thomas DJ. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Archives of Toxicology, 74: 289-299, 2000. DOI: 10.1007/s002040000134.

Vega L, Ostrosky-Wegman P, Fortoul TI, Díaz C, Madrid V, Saavedra R. Sodium arsenite reduces proliferation of human activated t-cells by inhibition of the secretion of interleukin-2. Immunopharmacology and Imunotoxicology, 21(2): 203-220, 1999. DOI: 10.3109/08923979909052758.

Gonsebatt ME, Vega L, Salazar AM, Montero R, Guzmán P, Blas J, Del Razo LM, García-Vargas G, Albores A, Cebrián ME, Kelsh M, Ostrosky-Wegman P. Cytogenetic effects in human exposure to arsenic. Mutation Research, Reviews in Mutation Research, 386: 219-228, 1997. DOI: 10.1016/S1383-5742(97)00009-4.

Rojas E, Valverde M, Vega L, Salvador A, Ramirez P, Herrera LA, Watters D, Lavin MF, Ostrosky-Wegman P. Genotoxic effects of bistratene A on human lymphocytes. Mutation Research, 367: 169-175, 1996. DOI: 10.1016/0165-1218(95)00097-6.

Vega L, Gonsebatt ME, Ostrosky-Wegman P. Aneugenic effect of sodium arsenite on human lymphocytes in vitro: an individual susceptibility effect detected. Mutation Research, 334: 365-373, 1995. DOI: 10.1016/0165-1161(95)90074-8.

Gonsebatt ME, Vega L, Montero R, Garcia-Vargas G, Del Razo LM, Albores A, Cebrian ME, Ostrosky-Wegman P. Lymphocyte replicating ability in individuals exposed to arsenic via drinking water. Mutation Research, 313: 293-299, 1994. DOI: 10.1016/0165-1161(94)90059-0.

Gonsebatt ME, Vega L, Herrera LA, Montero R, Rojas E, Cebrián ME, Ostrosky-Wegman P. Inorganic arsenic effects on human lymphocyte stimulation and proliferation. Mutation Research, 283: 91-95, 1992. DOI: 10.1016/0165-7992(92)90139-9.

Ostrosky-Wegman P, Gonsebatt ME, Montero R, Vega L, Barba H, Espinosa J, Palao A, Cortinas C, García-Vargas G, Del Razo LM, Cebrián M. Lymphocyte proliferation kinetics and genotoxic findings in a pilot study on individuals chronically exposed to arsenic in Mexico. Mutation Research, 250: 477-482, 1991. DOI: 10.1016/0027-5107(91)90204-2.